As long as your mount can handle the weight it should work fine.
I use a fixed 4.5 inc Newt as a guide scope-and by simply using longer exposures in the guide camera-sometimes up to 2 or 3 sec (very rarely though)-have never ever had a problem with finding a guide star. If you were to use aToUCam incapable of long exposures as a guide camera its another story--you then will most certainly need to adjust the guide scope--but that's not your plan anyway. So I'm certain it will work---as long as the mount can handle it
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