Mosaicing pre-stretching, PixInsight does that quite well.
Firstly you mosaic register the two of them together, then you register the individual images against the mosaic image which creates the individual images within the larger mosaic region. The you get those larger images use a script called something like GradientMergeMosaic or something.
I personally have been doing a quick process on each panel and then stitch them together using AutopanoGiga and then finish the processing.
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