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I've done away a long time ago with individual antivirus clients residing on each machine and now use a mix of hardware and clients when outside home network (e.g unsecure connection). MSE is getting very good but it still has been compromised 30% of the time as early as 2015. I would not rely solely on it yet. Having said that I know a lot of company infrastructures are using it and I don't know the latest implementation in Win10.
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