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I can't add much to what Russ said, other than to say that it depends on what you mean by high ISO. Different models of DSLR seem to have
different ISO "sweet spots", and many people use their Canon 1100Ds
and 1200Ds at ISO 1600, and sometimes 3200. You will see occasional
images here taken using 6400, and very occasionally, even higher.
From following threads here, I think Nikon users seem to frequently
use around 800-1000.
raymo
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