looks really promising -
Suggest that the light source may be a super hot pixel (or group), possibly generating light as well as dark current - yours is nowhere near as bad, but looks somewhat like
http://www.iceinspace.com.au/forum/s...d.php?t=127858
The horizontal column? defect is minor and can be processed out as others have suggested, either using column substitution or dithering and statistical rejection. Many popular chips have column defects from new, so don't sweat on it.
Overall though, provided that the defects remain stable and can be handled in processing, looks like a winner to me - nice work.