One less cable is one less thing to go wrong. So once you go down the path of connecting computer to mount I think it makes sense to drop the ST4 cable.
Connecting the computer to the mount opens up new possibilities aside from guiding. In my case I use Stellarium to slew the mount to the target then use AstroTortilla to plate solve and make the necessary adjustment to centre the target.
It also lets you use a guide camera that doesn't have an ST4 port.
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