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You do have to remember... even the best virtual machines cant run as fast as a native app. So running anything through fusion/parallels it wont run as fast or as well as if it was running on a windows machine, or via bootcamp. That's not to say they wont run... and run fine most of the time... but they can't quite run as fast as native. That's just the way of virtual machines.
90% of the time USB devices work fine in virtual machines... but I have seen the odd device here and there that just doesn't like them... maybe your USB to Serial is one of these.
Also, if it's an older USB to Serial you may have problems. I have one that's about 6 years old, that wont run under Windows 10, but I have a newer one that works fine. Some of the old devices they just haven't bothered creating new drivers for.
Geoff.
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