[glend (Glen)]

Unless your going for total computer control of the camera the boxes will have an impact on useability. In my case I like having manual control of the setup, including ISO, framing using Liveview (even collimation tweaks through the camera). I hate BYEOS because if used for framing and focusing it automatically changes my camera setup, defaults it to jpeg, switches ISO, etc and unless you program in capture through it, as opposed to say using and intervalmetre, it leave the camera with the framing setting. It also requires an additional USB cable to my laptop which there is no room to plug in. Yes, a new laptop or usb port device may solve that problem eventually but the workflow process I have now using Liveview suits me just fine. Thus I need access to the buttons, controls, and screen.
I will concede that a sealed box offers a big advantage in condensation control, providing a dessicant repository, and can contain dry gas purges better than other solutions. The challenge there is the sealing,specially around cold finger exits, front adaptor, etc. If you exit a coldfinger through a box it becomes a permanent part of the camera, requiring disassembly to remove the box - unless you build a slot in the box to slide it off - another sealing challenge.
Another consideration with a box is keeping the camera from moving around, and stress on the cold finger sensor joint.

I look forward to what creative minds, younger than mine, can come up with to solve these problems.