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I bin 2x2 when I can't find a bright enough star. I'm more likely to bin my guider than change the framing of the subject.
With ccdsoft and adaptive optics the guider is set to bin 2x2 by default in an attempt to get stars bright enough for fast guiding. I haven't had too much experience with it yet but in the 7 or 8 tests I've done binning 2x2 has allowed 0.5 - 0.1sec guide exposures...
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