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Well Brent, as a general rule of thumb, aim for a pixel scale of 1 to 1.5 arcsec, and you'll be okay in most situations. With my QHY22 I operate at a somewhat undersampled scale for my ED80T (at 2.44), but drizzle stack it, and a little oversampled at about 0.92 with 10" f/4. Quite flexible really.
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