Hi David,
I travel by plane regularly, up to 12 hours at a time, and find the noise cancelling headphones enhances the trip.
As indicated in the other posts, they don't cancel out irregular or sudden noises but the constant background hum.
I use Bose 'over the ear' headphones (I do have in-ear 'phones as well for when I'm working in the garden or at the gym) and find them more comfortable when wearing headphones over an extended period of time.
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