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I might be wrong here, but your camera has a "native" ISO usually around 100-150 and setting it to higher ISOs simply increases the entire exposure (noise and all) in the camera instead of later in your post processing.
In this sense, it's convenient to be able to see your target in your subs and then stack for noise reduction etc which is the benefit of higher ISOs. Ultimately you could shoot everything at ISO 100 and amplify everything yourself in post later if you wanted.
I tend to shoot at a "high enough" ISO to see the target but theres really no need to push it higher in camera if you are going to push it later in post anyway.
Please let me know if I'm off track!
d
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