With hire cars you can definitely take them up to the Visitor centre at about 9000ft, but I believe not beyond that. Personally I wouldn't try the summit road in anything other than a good 4WD, its pretty rough.
With acclimatising, they stop at the visitor centre for a bit and a meal before heading up to the summit. If you have any major respiratory issues or cardiac issues it is worth getting advice first. My first trip we only stopped for 10mins at 9000ft and it definitely affected me at the summit, nothing serious just a bit lightheaded, and couldn't figure out how to use my solar scope!
Malcolm
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