Hell yes.
Both Celestron and Skywatcher have polar alignment functions in the mount. Maybe the iOptron does too. If you find a polar alignment method that works for you, you're in business.
If you just do 30sec subs, you can use a simple remote release.
This was a 300mm lens, but a standard 50D, 30 second subs unguided.
https://farm4.staticflickr.com/3900/...660c5487_z.jpg
Andromeda Galaxy (M31) by
stevetla, on Flickr
This was the same 50D and 200mm lens, 20 sec subs unguided. I've converted it to negaitive as it's easier to see the 204 galaxies that have been identified in the shot.
https://farm4.staticflickr.com/3898/...1eb47474_z.jpg
Virgo cluster labelled by
stevetla, on Flickr
Steve.
PS. Welcome to IIS.