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You can reduce the noise by stacking multiple images, or by using a program like NeatImage. For the moon you won't need more than ISO100 because it's so bright and your shutter speed is fast anyway, but for other fainter objects you'll probably want at least 200 to let more light in and reduce exposure times.
That's a very nice image MiG, focus is spot on. I did a slight reprocess in Photoshop and NeatImage to show what can be done. Hope you don't mind.
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