Darren
NGC 253 is the pick at the moment, nearby is also NGC 55 which is a nice galaxy. The cluster Wayne mentioned is the Grus Quartet (add in NGC 7552 to make it a quartet!) but the he mentioned are easy in one field. Can be a little faint if any light pollution is present.
In a short while the Fornax cluster starts to become easier, unless you are willing to stay up quite late!!
Malcolm
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