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For noise reduction I now use the TGVDenoise process in Pixinsight, on the unstretched image. Its not as heavy-handed as some of the other noise reduction options. Experiment with the settings, using (as a starting point):
Strength: 0.5
Edge Protection: 0.0002
Smoothness: 2.0
If you still need some noise reduction after stretching, then increase the strength and edge protection by approx 5-10x
ie
Strength: 2.5 to 5.0
Edge Protection: 0.001-0.002
Smoothness: 2.0
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