Collimation of laser collimators is easy to verify and fix if necessary. Also, given the small amount of play available in the draw tube, centring the laser collimator is not essential. Far more important is mounting it parallel to the optical path, since even a tiny angular error can have a noticeable effect on the outcome. Glatter makes a special 2"-1.25" adapter that ensures a parallel fit of 1.25" barrels in 2" draw tubes.
The actual issue with relying on laser collimators only is that you can mis-align the primary and still be able to contort the secondary into a position so that the laser spot returns to its origin. As the only source of truth a laser collimator is insufficient. However, if the position and rotation of the secondary is checked with a sight tube or one of those combined sight tube/cheshire/cross-hair tools then a laser collimator can get you close to very good collimation very fast.
Cheers
Steffen.
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