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This is a dark art I am afraid, I wish it was not.
I have a Canon 20d, SBigST2000xm, QHY5, an Opticstar 616C, a moonlite focuser with serial interface and a G11G with a serial interface, I can get most of these, but not all to work at the same time, via a usb hub. FWIW the issue seems to be in the chipsets, the QHY5 simply will not cohabit with the Opticstar nor is that happy with the Belkin serial/usb I use to drive the G11, under the covers it appears many USB devices are in fact serial - just with onboard convertors.
Plug in/power up order can be important so build up your config one device at a time and then, once you have a working setup, always use the same plugin/power up sequence.
I suggest you use a powered USB hub with a mains suply, many laptops will not provide enough power for multiple devices - the QHY5 is a known power hungry device.
Make sure your laptop is not running agressive power saving schemes (that can shut down usb devices) or unnecessary services (eg internal cameras), keep total cable length to 5m or less (25 m if you have active repeaters). And this last piece of advice you will not like. If you use two cameras like I do you should have them plugged in to two separate USB ports on your laptop (that means two cables sorry)- and make sure those are in turn on different controllers on the pc/laptop (check in the device manager). That is the only way I have reliably been able to prevent conflicts, a possible alternate is to use the same s'ware for guiding and acquisition so that frame downloads cannot conflict and cause issues.
Good luck!
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