At higher power levels it can for hi spec systems. My feeders to the back speakers (50 litre AudioLabs ) is 5mm braided shielded copper. Prevents crosstalk and lagging of hi frequencies.
For normal listening and domestic systems, not really. Although I'd always like to see good well connected multi-strand copper wire used regardless, not some cheap trurip twin bell wire stuff.
Regardless make sure your connections are clean and well secured.
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