Hi Entropy,
Is that link the actual full size image? it looks pretty nice and well framed my comments (i am no means an expert - and have no experience with Pixinsight).
It appears to me that you might have more nebula in there to bring out and you may have overdone the 'highlights' or upped the contrast a tad too far?
Still, very nice though - and i hear Pixinsight has some serious learning curves!
Rusty