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If you're serious and want to go mono ultimately then I wouldn't bother with OSC, especially if you already have some experience with a DSLR.
The 11K sensor and the FSQ-106 is a great combination and will give you a very wide FOV of approximately 3.9x2.6 degrees. It's great for large objects and fields. At an image scale of 3.5 arcsec/pixel guiding and seeing don't need to be fantastic to get a great result and the combination of fast scope and big pixels will collect data quickly. The only downside is that you won't have the resolution to do small objects justice.
Another option would be to go with a sensor with smaller pixels. That will get you better resolution at the expense of a smaller FOV. The ICX-694 and KAF-8300 sensors would be worth thinking about if you want the extra resolution.
QE does vary significantly across different sensors. As well as peak QE you might also want to look at the QE at different wavelengths and think about what you'll be imaging (e.g. Ha is important for emission nebulae, good QE for the blue region would be useful for galaxies.) Another important camera parameter is read noise - the lower the better.
Cheers,
Rick.
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