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A 12" should easily sweep up NGC2207. It is not far from Mirzam (Beta Canis Majoris) Which is the bright star immediately west of Sirius. Canis Major will be close to directly over head about midnight which is not always easy with a dob, but give it a try anyway!
From Mirzam move about 2deg south then very slightly west in in your finder you should see a triangle of stars about 1deg wide that are vis in the finder but probably not with the naked eye. Find the star firthest from Mirzam and then search the area south west of that for an elongated smudge.
Malcolm
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