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That looks like straight vignetting to me. What size filters are you using? Mike reported the inch and a quarter filters were causing some vignetting but the 36mm ones he got do not vignette.
I also find using a microfibre lens cleaning cloth very handy. I wipe the camera CCD window several times with it (the small dust particles are hard to see). You have a couple of hard dust donuts there I would physically wipe clean rather than rely on flats to remove them. One is also quite close to the target object.
I don't see any star bloat in your image. How long are those exposures of NGC1365?
I should check the adapters but probably not a source of issue for me. I use the same setup with my FLI Proline with no problem so its related to the camera not the setup.
Greg.
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