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Average and sum will give you effectively the same result except that a sum could overflow if Maxim is using integer arithmetic (it probably doesn't but you might as well use average to be safe).
Median will give you some rejection of satellite trails, cosmic rays (and hot/cold pixels if you dither) that you don't get with average but it also gives you a lower signal to noise ratio (about 20% less).
An average combine with a suitable rejection algorithm should usually give you the best of both worlds.
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