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Simon. Dithering is your best friend. But it is not a replacement for proper calibration - bias darks and flats. Dithered images are flatter and cleaner. While calibration frames remove unwanted signal, fixed pattern/bias, thermal and optical train, dithering increases sampling over the image and hides imperfections in calibration. This is particularly relevant to DSLRs without any form of temperature control. Random noise is also ironed out. I dither by about 10 - 15 pixels.
You will notice that colour calibration is difficult with uncalibrated images, which makes post processing difficult as well. Hope that helps.
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