I've had good results with CCD Commander. Meridian flips work well, depending on how orthogonal your OTA is - although a T-point model might negate that.
CCDC does a plate-solve and resync after a meridian flip (although you could turn that off if you wish). I've left it run overnight unattended with a 600mm focal length, but it often needs a bit of supervision with my 1800mm scope - this is on a temporary setup with no pointing model.
Once you've used scripted imaging, you won't go back to manual. It can click the buttons, slew to a focus star, refocus, slew back to your target, start imaging again with a new filter, park and the end of the night, wake itself up when it needs to take dawn flats, etc, etc, far more efficiently than you can!
Even when I'm up at Leyburn, I still run a script so that I can wander around and chat, watch a DVD or catch some Zzzzzzs.
DT
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