I haven't seen this kind of problem with my ME.
What's the connection of your guider, are you using Direct Guide? What software are you using, CCDSoft?
I wonder if your guider calibration is incorrect somehow.
Do you see the same behaviour with guiding turned off or is it guiding which is introducing the problem?
I can track for easily over 3 minutes anywhere in the sky with no DEC drift @ bin 1x1. I autoguide for anything over 3 minutes. My autoguiding is quite steady, star snaps back to the centre instantly every time.
I use aggressiveness 10 and Direct Guide with CCDSoft doing the camera/guiding.
Not sure off the top of my head what my guide chip's pixel scale is. The ST8-XME is at ~0.86/pixel @ 1x1.
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