Yeh, me too. It seems that these kind of things are exhibited variably by the QHY5 cameras, and it could be something driver specific.
I've got a couple of things to look at with regard to the bayer pattern, and I guess it's possible the bayer pattern is causing this issue although I don't think so. The bayer pattern causes a fluctuation between adjacent columns of pixels when binning my spectra, see attached, but this goes away when I co-add a few frames. I can't see how the bayer grid would cause the wider range response fluctuations though.
As stated flats would probably get rid of this, but I'd rather find out the root cause. Keep on keepin' on.