Once upon a time, mirrors had a bare naked film of silver of aluminium on it. It was a very hard thing to clean without damaging the surface and the best advice was leave well alone.
Nowadays, like steffen says, most mirrors have a silicon over coating which achieves two things. Firstly it stops the reflective coating from tarnishing, hurrah, and secondly it provides a robust outer coat to protect the mirror, double hurrah!
Still, always be careful cleaning your mirror, but do it whenever you like. Use very light pressure with soapy water and cotton wool then rinse off with distilled water. Don't scrub, but don't be too afraid!
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