short answer is No.
I did several runs on Jupiter this morning with the 2.5x and 4x powermates. I've featured the best of the 2.5x run in another thread, but wanted to compare and contrast the image taken with the 4x powermate with one through the 2.5x powermate resampled up to match the same image scale.
The difference is striking at least under the conditions present - ranging from 5-7/10 seeing. The image just breaks down with the 4x powermate, I have to crank the gain up too far to use it. The 2.5x seems optimal for this setup and conditions and so the resample looks much better. Seeing may have been marginally worse for the 4x shot, but not to the extent suggested by the difference here.
I've used the 4x on Jupiter under 8/10 conditions and while the image is better it's still not as good as what I can get with the 2.5x. I reckon I'll be waiting for an elusive 9/10 to really make the most of 4x.
It seems, at least sometimes, it pays to resample rather than push up the image scale.