M42 can be a tricky one as raymo says, but I'd say give it a go... from a capturing point of view, it presents a challenge as it's very bright and quite large, and there's the huge dynamic range raymo mentioned between the core, where all those lovely trapezium stars are buzzing away, like kids on sugar drinks
which makes it really really bright. Then you've got the colourful bowl and then the outer reaches of the sail and beyond.
If you have a look at my attempt
http://www.iceinspace.com.au/forum/s...d.php?t=128452 you'll see I've taken multiple sets of exposures, mostly 2 minutes but then some much shorter ones to represent the core...which was composited with the rest during processing.
I used the same ISO, which probably wasn't very smart...but try changing your camera settings and exposure lengths and see how it comes out.
The Tarantula nebula in the LMC is also a tricky one, I intend to use a similar tactic as M42 for that one...