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1) Yes you can but as mentioned you don't really need to do it, the noise added by sensor heat is probablya lot more than the blur by the mirror vibration. In my experience mirror lockup makes sense when the exposure time is from 1/50 to 1 second. Beyond that the exposure is just too long for the shake to affect the shot.
2) Please don't even try. Even if you could mount the 10-22 it will vignette and you can only use about half of the frame. If you move to a 5DII just sell the 10-22 and get a 17-40 instead.
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