I run Win10x64 pro on my Obs toshiba laptop....with no dramas at all
Not sure which MKS controller you are using.
You need to install the MKS4000 (or MKS5000) drivers as well as SkyX
But you will need to use USB, RS232 or Wi-Fi (if the option is installed) to talk to the mount regardless.
Not sure why you would want to use ASCOM to control the mount
....if you have the SkyX...Bisque's native drivers are extremely stable