Median combined sky flats are perhaps the best way to go, especially of you point the scope at a bunch of different areas in the sky to alter any gradients present. the median combine removes the gradients leaving behind a very good vignetting profile and all your dust bunnies.. Having said that, I use a LED Flat box that Robin made for me, it works well, however I do rotate the flat box around between flat frames to make sure any non-uniformity is compensated for..
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