long exposure noise reduction
if you are looking to get a single shot in camera I would use a noise reduction tool later as it should be better than what is built into the camera. but do make sure it still takes its long exposure dark frame though, some cameras let you disable it, some dont.
if you intend to align and stack images then disable in camera noise reduction completely, the more subs you take the better the innate noise reduction becomes. you can never eliminate noise without damaging signal. this is pretty much exclusively how I work, i dont care much about exposure in camera except maybe moon.
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