What mount and scope are you using? Focal length?
What autoguide settings have you set? (exposure length, min/max move)
Even with a reasonable polar alignment a long focal length scope guide star can drift. If your mount has high periodic error then this could drift a lot or if the polar alignment is badly off or the mount poorly balanced it can drift a lot.
Do you get round stars in 10 minute exposures at 1x1 binning?
Greg.
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