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Frank - it's when you change colour "models" from RGB (which is what you use) to CMYK for printing in a magazine or book that you have to worry about compensating for colour shift as your image is separated. Printing to a common poster as Brendan is suggesting usually means staying within the RGB colour model.
You should be able to go quite large too - even up to A1 or A0 on 12MP. Remember - it's a very large poster, designed to be seen from a reasonable distance - not at arm's length like a magazine. Therefore resolution is not as critically important, and you can stretch quite a ways. At poster size, even 15-25 dpi is fine.
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