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I agree with Glen. Just did a quick calculation and the ASI1600 mono up at my dark site would take about 150s (gain 0) to become sky limited, the same time as my QHY22. The ASI has a lower read noise but the QHY has larger pixels and a higher QE.
At gain 200 that drops down to 20s but you lose a LOT of dynamic range in the process.
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