Here is a picture showing the difference in binning.
I found that I had to bin at 2x2 & expose for 900 seconds to get any of the spiral arms to show up on NGC 300.
I use a KAF8300 sensor with a 10" f4 Newt.
The final LRGB picture is here:
https://www.flickr.com/photos/247194...in/photostream
cheers
Allan