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Binning is a bit like megadata. Ideally you alway use 1x1 but sometimes its time efficient to use 2x2.
2x2 is fine for non critical detail in images like O111, S11, Ha if its not full of detail or the main item in the image.
If you want the best possible image and have tons of time, clear skies, no bad weather and reliable gear then sure go for 1x1 and add up the signal to noise ratio.
Greg.
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