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It should be possible to run it all from one computer. A lot will depend on enough connections from the PC and the software you use.
I did a G11 and a Polarie at the same time. I used APT with the CCD, and BYEOS with the 6D on the Polarie. I have a 7 port USB hub and everything connected to that ok. Of course my setup in this case is much simpler since I didn't need to guide/control the Polarie.
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