Out of the QGuider and the Orion at this stage I'm happy with my choice to go with the QGuider. I did have troubles with the autoguider cable but that's my fault for not wiring it right. USB cable adds to the cost if you need to buy it. I am still sorting out the guiding, trying to get it working right, but I think that I'd be using the same software with either camera so don't think one would be easier than the other.
The QGuider is cheaper, that's what it comes down to.
Having used the QGuider the only thing I wish is that it had some form of cooling to keep it's noise level down. I've considered glueing a peltier on to it. I expect the Orion would have the same noise issues. Software dark frame reduction obviously reduces the impact of this, if you use software that supports dark frame subtraction. Anyway, same issue of noise would be there for both cameras.