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There's more to flats than just vignetting & "obvious dust donuts". Can you be sure you have no dust or anything else in your imaging train? Camera, filters, reducers, lenses (inside or out). What about water spots forming on the lens during an imaging session from moisture in the air? You can take all the precautions you want but you will never get everything. So yes, do the flats - a few minutes that will save pain later.
Cheers,
Mark
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