it shouldn't make any difference.
most common cameras have around 11-12bits dynamic range (this camera has very slightly more than 12 bits, so it is better than many). The lower bits in 16 bit cameras are generally dominated by read noise, so they do not contribute anything to an image. 12 bits is sufficient to encode almost all of the available dynamic range from the ZWO camera, so no problems.
http://olympus.magnet.fsu.edu/primer...amicrange.html
http://www.photometrics.com/resource...amic-range.php