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It could be a driver issue.
I use a QHY8/Neb2 for imaging and a QHY5/PHD for guiding.
My problem was, the QHY8 would download rubbish while the QHY5 was active. Different to your issue, I know.
The Neb2-PHD link should disable PHD during image download only, and your issue seems to happen while the QHY8 is exposing a sub. Very unusual as there is no traffic on the USB during exposure.
Does it affect PHD only during calibration, or during guiding as well?
In any case, I re-installed the QHY8 and QHY5 drivers, re-started the PC and all is OK now.
Cheers,
Rob
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