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I would suggest you place the scope or the packing around the scope on some kind of bubble wrap or foam bed to absorb any shocks that may happen on the road. This should help reduce the shock to the scope and limit the impact on the alignment.
Checking collimation is always a good idea. I have taken mine about 30 minutes to a darker site just laying in the back of the SUV with no packing. I lay it on foam mats of the type you use on a shop floor. Has held collimation quite well.
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