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Sorry Rob but no can do. Flats need to be taken at the same binning and with the same filter as the lights. The time for flats though can be very short (some say less than a sec, others recommend up to 10 sec and then take flat darks) not like darks that need to be the same length as your lights (or close if you are taking bias frames and scaling).
One of the things flats do is to 'normalize' any quantum efficiencies between pixel across the frame. You can't do that if you take 4 pixels, make them one big pixel and then try to split that again back into 4 pixels.
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