On the focus side - I use a Bhatinov mask - first get the main camera perfect on a bright star, then zoom on Jupiter in the guide camera, take long duration shots and adjust only your guider's focus in the OAG.
Jupiter is large enough to give a differaction pattern in PHD for me.
In those guided shots I posted - tracking and is better than +/- 3 arc seconds for well over several hours - so it is achievable.
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