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I don't worry too much about being on the meridian, but if you are using pulse guiding via ASCOM it is best to do it on or near the equator to get the most consistent results. You may not even have to re calibrate after a meridian flip depending on setup. If you are using ST4 guiding via a cable you need to calibrate on initial startup and re calibrate any time you change dec by any significant amount, and if you do a meridian flip. I just use any suitable star that is well away from the edge of the field of view so there is no chance of it moving out of view during calibration.
If you are using PHD2 for drift alignment, you need to set up, calibrate, do your drift alignment then re calibrate as the axis angles it computes will have changed.
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